Feed / XENE

Xenon Pharmaceuticals Inc.

XENE

Healthcare · 58.84 -0.2% today

Isolated · not yet confirmedMarket checked 10 Sept, 15:55 GMT-4

Market read

Xenon Pharmaceuticals Inc.'s current read is isolated; its market group is not confirming.

The latest filing evidence is available. 0 of 2 group members are active now; 0 filing-linked outsiders are moving with the group, and 0 of 3 directly disclosed connections are confirming.

What changed
  • The operating loss widened by 28.9M.
Company-0.2% todayVolume comparison unavailable
Market group0 of 2 activeBiotechnology Stocks · unavailable
Disclosed network0 of 3 confirmingNo filing-linked name is confirming now
What would change this read
  • Xenon reports higher R&D spending tied to azetukalner Phase 3 studies and manufacturing for a planned NDA submission, with no revenue in the latest three months.
  • Direct external costs for azetukalner increased by $15.6M in the quarter, attributed to ongoing Phase 3 clinical studies in MDD and BPD.

Invalidation: The isolated read changes if XENE's group or a disclosed connection begins moving with it.

Watch this read

Research brief

The story so far

Healthcare · Biotechnology

The latest filing evidence is available. 0 of 2 group members are active now; 0 filing-linked outsiders are moving with the group, and 0 of 3 directly disclosed connections are confirming.

Evidence that supports

No thresholded supportive filing evidence is available yet.

Evidence that challenges
  • The operating loss widened by 28.9M.
  • Operating cash flow remained negative at -184.3M.
  • Cash declined 15.9M versus the comparable period.
What would clarify the read
  • Xenon reports higher R&D spending tied to azetukalner Phase 3 studies and manufacturing for a planned NDA submission, with no revenue in the latest three months.
  • Direct external costs for azetukalner increased by $15.6M in the quarter, attributed to ongoing Phase 3 clinical studies in MDD and BPD.

Company research

Understand the business, not just the ticker

As of Sep 11, 2026
Business model and earnings drivers

Use the company’s filings to identify the few operating, demand, cost, capital and regulatory variables that determine its earnings power.

Key research questions
  • Which operating variable is changing?
  • Is that change durable, cyclical or one-off?
  • What evidence would disprove the current interpretation?
Annual periods9
Price observations327
Usable filing statements53
Verified relationships2
Evidence supporting the case

No qualifying supportive evidence was identified.

Evidence challenging the case
  • Foreign exchange has repeated adverse evidence across 5 filings.
Questions before a position
  • EV/sales is 3589% above the available filing-peer median; determine whether growth and quality justify the difference.
Longer-term price context

Price as of Sep 10, 2026

58.84
6m-0.3%12m+56.9%24m
Annual trajectory

Reported annual revenue and per-share history. This is accounting history, not a forecast.

PeriodRevenueYoYDiluted EPSShare change
2021-12-31$18.4M-42.7%$-1.77+26.3%
2022-12-31$9.4M-48.8%$-2.06+38.8%
2023-12-31$0-100.0%$-2.73+10.5%
2024-12-31$0$-3.01+16.5%
2025-12-31$7.5M$-4.36+1.7%

What management says matters

Persistent and emerging business drivers

Foreign exchangenegative · 5 filings
The foreign exchange gain decreased by $2.0 million and $1.5 million for the three and six months ended June 30, 2026, respectively, due to fluctuations in the value of the Canadian dollar, partially offset by a lower balance of cash and cash equivalents and…
10-Q · Aug 6, 2026
Product pipeline and R&Dmixed · 5 filings
The increase in cash used in operating activities was primarily driven by higher research and development and general and administrative expenses, no revenue recognized in the six months ended June 30, 2026, lower cash received from interest income, and chang…
10-Q · Aug 6, 2026

Valuation discipline

Descriptive valuation snapshot

Price/sales 621.8× · EV/sales 595.2×. Comparisons use only industry-matched filing peers.

Scenario scaffold

Mechanical 2.0-year scenarios are available as editable assumptions, not consensus.

Price action

How the market is pricing the story

58.84-0.2% today

Jodie does not have enough daily observations to draw a useful short-term chart for this asset. The latest quoted price was checked 10 Sept, 15:55 GMT-4; this is a coverage limitation, not a flat-price conclusion.

Developments

No sourced recent-development timeline yet

Jodie has not returned a relevant primary source or news item for XENE. This is an evidence-coverage gap, not a conclusion that nothing material happened.

Business and financial condition

Reported financial figures are not available yet

Jodie has not returned structured SEC XBRL fundamentals for this asset. This is a coverage limitation, not an assessment of the business or its financial health.

Latest filing assessment

The latest filing has limited comparable evidence

10-Q filed 2026-08-06 against the comparable filing from 2025-08-11.

limited evidence
OperationscautiousEvidence score -1
liquiditycautiousEvidence score -2
valuationwithheld

Capital and cash conversion

Reported investment and cash context

Capital spending YoY
+104.0%

Capex, revenue, and operating cash flow are matched to the same reported duration. Reported accounting context, not a forecast or trading recommendation.

What improved

No thresholded improvement was identified.

What weakened

  • The operating loss widened by 28.9M.
  • Operating cash flow remained negative at -184.3M.
  • Cash declined 15.9M versus the comparable period.

Filing receipts

2025 2026 2025 Increase/(Decrease) 2026 2025 Increase/(Decrease) Direct external costs: Azetukalner $ 55,760 $ 43,405 $ 12,355 $ 102,833 $ 74,906 $ 27,927 Pain programs 5,582 925 4,657 9,973 1,977 7,996 Pre-clinical, discovery and other programs 4,683 5,186 (503 ) 7,641 9,101 (1,460 ) Indirect costs: Personnel-related (including stock-based compensation) 28,557 22,869 5,688 58,442 44,176 14,266 Other unallocated expenses 4,642 2,600 2,042 8,843 6,025 2,818 Research and development expenses $ 99,224 $ 74,985 $ 24,239 $ 187,732 $ 136,185 $ 51,547 Direct external costs related to azetukalner increased by $12.4 million and $27.9 million for the three months and six months ended June 30, 2026, r...

39 $ 187,732 $ 136,185 $ 51,547 Direct external costs related to azetukalner increased by $12.4 million and $27.9 million for the three months and six months ended June 30, 2026, respectively, primarily due to our ongoing Phase 3 clinical studies in the MDD and BPD programs, as well as manufacturing activities to support our planned NDA submission.

Pain programs costs increased by $4.7 million and $8.0 million for the three months and six months ended June 30, 2026, respectively, primarily due to our ongoing Phase 1 clinical studies of XEN1701 and XEN1120, as well as manufacturing activities to support the clinical studies.

Historical filing backfill generated after the original filing window. It is not part of Jodie's live track record.

Business ecosystem

The relationships behind XENE

Customers, suppliers, partners and competitors named in company filings—not inferred from headlines.

Depends on

NBIXNeurocrine Biosciences, Inc.partnerMay 7, 2026

Our Partnered Program with Neurocrine Biosciences In December 2019, we entered into a license and collaboration agreement with Neurocrine Biosciences to develop treatments for epilepsy.

JAZZJazz Pharmaceuticals plccompetitorFeb 26, 2026

There are other ASMs in development that could potentially compete with our products, including product candidates in development from Biohaven Ltd., Jazz Pharmaceuticals, plc, Neurona Therapeutics Inc., NeuShen Therapeutics, Inc., Otsuka Pharmaceutical Co.

Depended on by

NBIXNeurocrine Biosciences, Inc.partnerFeb 11, 2026

Some of our other collaborators include Nxera Pharma UK Limited (formerly Sosei Heptares), Takeda Pharmaceutical Company Limited, Voyager Therapeutics, Inc., and Xenon Pharmaceuticals Inc.

Filing peers

Companies whose filings use similar operating language.

Open the three relationships above to see Jodie’s filing proof. Pro unlocks every receipt, and alerts when connected names begin moving. Unlock the full network →

What is moving around it

Live connections

XENE is currently a Leader in the organic co-movement group Biotechnology Stocks. This group is discovered from market behaviour rather than assigned from an industry taxonomy. 3 filing-linked names are in the relationship map; none is currently confirmed as moving with the group.

Context history

Theme membership history

No durable theme membership has been observed for this name yet.