“nd Royalties Cost of collaborations and royalties decreased during the year ended December 31, 2025, as compared to the year ended December 31, 2024, primarily due to decreased demand for GalNAc material supplied to our collaborators in support of certain pro…”10-K · Feb 12, 2026 ↗
Alnylam Pharmaceuticals, Inc.
ALNY
Market read
Alnylam Pharmaceuticals, Inc.'s current read is isolated; its market group is not confirming.
No new filing conclusion is available. 0 of 15 group members are active now; 0 filing-linked outsiders are moving with the group, and 0 of 22 directly disclosed connections are confirming.
- A routine FDA inspection at a CMO resulted in a pending '61' inspection classification, prompting an amendment to the vutrisiran submission and delaying the PDUFA action date and NDA approval.
Invalidation: The isolated read changes if ALNY's group or a disclosed connection begins moving with it.
Research brief
The story so far
No new filing conclusion is available. 0 of 15 group members are active now; 0 filing-linked outsiders are moving with the group, and 0 of 22 directly disclosed connections are confirming.
No thresholded supportive filing evidence is available yet.
No thresholded adverse filing evidence is available yet.
- A routine FDA inspection at a CMO resulted in a pending '61' inspection classification, prompting an amendment to the vutrisiran submission and delaying the PDUFA action date and NDA approval.
Company research
Understand the business, not just the ticker
Use the company’s filings to identify the few operating, demand, cost, capital and regulatory variables that determine its earnings power.
- Which operating variable is changing?
- Is that change durable, cyclical or one-off?
- What evidence would disprove the current interpretation?
- Latest annual revenue changed +65.2% year over year.
- Operating margin changed +21.4 percentage points in the latest annual period.
- Net margin changed +20.8 percentage points in the latest annual period.
- Operating cash flow covered net income at 1.67x in the latest annual period.
- Diluted shares increased 5.5% in the latest annual period.
- P/E is 209% above the available filing-peer median; determine whether growth and quality justify the difference.
- EV/sales is 81% below the available filing-peer median; determine whether growth and quality justify the difference.
Price as of Sep 11, 2026
248.86Reported annual revenue and per-share history. This is accounting history, not a forecast.
What management says matters
Persistent and emerging business drivers
“Selling, general and administrative expenses increased during the year ended December 31, 2025, as compared to the year ended December 31, 2024, primarily due to higher employee compensation costs, including stock-based compensation, mainly driven by higher h…”10-K · Feb 12, 2026 ↗
Valuation discipline
Descriptive valuation snapshot
Price/sales 9.0× · EV/sales 8.6×. Comparisons use only industry-matched filing peers.
Mechanical 2.0-year scenarios are available as editable assumptions, not consensus.
Price action
How the market is pricing the story
Jodie does not have enough daily observations to draw a useful short-term chart for this asset. The latest quoted price was checked 11 Sept, 15:55 GMT-4; this is a coverage limitation, not a flat-price conclusion.
Developments
No sourced recent-development timeline yet
Jodie has not returned a relevant primary source or news item for ALNY. This is an evidence-coverage gap, not a conclusion that nothing material happened.
Business and financial condition
Reported financial figures are not available yet
Jodie has not returned structured SEC XBRL fundamentals for this asset. This is a coverage limitation, not an assessment of the business or its financial health.
Filing analysis
No comparable filing assessment is available yet
Jodie has not yet found a suitable current-versus-prior filing comparison for ALNY. This does not mean the latest filing was neutral or immaterial.
Business ecosystem
The relationships behind ALNY
Customers, suppliers, partners and competitors named in company filings—not inferred from headlines.
Depends on
REGNRegeneron Pharmaceuticals, Inc.partnerApr 30, 2026 ▾
“Our collaborator, Regeneron Pharmaceuticals, Inc., or Regeneron, is advancing cemdisiran in combination with its anti-C5 monoclonal antibody, pozelimab, in a Phase 3 clinical trial 6 Table of Contents in paroxysmal nocturnal hemoglobinuria, and as a monothera…”
AAgilent Technologies, Inc.supplierFeb 12, 2026 ▾
“In 2015, we amended our manufacturing services agreement with Agilent Technologies, Inc., or Agilent, to provide for Agilent to supply, subject to any conflicting obligations under our third-party agreements, a specified percentage of the active pharmaceutica…”
Depended on by
REGNRegeneron Pharmaceuticals, Inc.partnerApr 29, 2026 ▾
“Alnylam We and Alnylam Pharmaceuticals, Inc.”
Filing peers
Companies whose filings use similar operating language.
Open the three relationships above to see Jodie’s filing proof. Pro unlocks 19 more links, every receipt, and alerts when connected names begin moving. Unlock the full network →
What is moving around it
Live connections
ALNY is currently a Leader in the organic co-movement group Broad Market Risk. This group is discovered from market behaviour rather than assigned from an industry taxonomy. 3 filing-linked names are in the relationship map; none is currently confirmed as moving with the group.
Context history
Theme membership history
No durable theme membership has been observed for this name yet.